1,6-Diamino-dihydropyridine and triazolo[1,5-a]pyridine analogues as a highly promising coumarin scaffold for the development of bacterial infection inhibitors

• Published in: Chemical Data Collections Vol. 28; p. 100487
• Main Authors: Naik, Nirmala S., S, Samundeeswari, Chougala, Bahubali M., H, Megharaja, Pawar, Varsha, Gudimani, Parashuram, Shastri, Lokesh A., Dodamani, Suneel, Jalalpure, Sunil, Sunagar, Vinay
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-08-2020
• Subjects: Bacterial infections; Dihydropyridine; Triazolo[1,5-a]pyridine anti-inflammatory and coumarin; Triazolo[1,5-a]pyridine anti-inflammatory and coumarin; Bacterial infections; Dihydropyridine
• ISSN: 2405-8300; 2405-8300
• DOI: 10.1016/j.cdc.2020.100487

•Keeping in mind the biological activity of coumarin and pyridino-triazole scaffolds were designed and synthesized successfully using ecofriendly method.•The method is highly economic and simple experimental condition.•The antimicrobial and anti-inflammatory activity results are quite promising and these scaffolds are prime candidate for the further drug development.
A new, extended coumarin scaffold was successfully explored for the construction of effective bacterial infection inhibitors. A reliable methodology for the synthesis of Dihydropyridine 4 and triazolo[1,5-a]pyridine 6 analogues in a three-component Michael type addition reaction was adopted and afforded excellent yields. All the structures have been established by spectral analysis. The evaluation of the antimicrobial profile against Gram positive, Gram negative bacterial stains and fungal stains revealed that the title compounds are highly potent. The antimicrobial profile suggests that the compounds are selective and highly active against S. aureus and E. coli stains. Similarly, all the compounds are highly promising and potent against A. flavus fungal stain. Additionally, these scaffolds exhibited good anti-inflammatory activity in comparison with standard Aceclofenac.
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