Clinical Applications of Fetal Cell-Free DNA: State of the Science

Advances in technology have correlated with expanding prenatal genetic testing options for pregnant people. Leading medical organizations recommend cell-free DNA as the most sensitive screening test for trisomies 13, 18, and 21, as well as for fetal sex chromosome aneuploidies. The commercially avai...

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Bibliographic Details
Published in:	Journal of midwifery & women's health
Main Authors:	Knutson, Julie, Anthony, Kathryn, Russo, Melissa L, Kole-White, Martha B
Format:	Journal Article
Language:	English
Published:	United States 25-07-2024
Subjects:	prenatal genetic testing noninvasive prenatal screening (NIPS) noninvasive prenatal testing (NIPT) cell‐free DNA (cfDNA)
Online Access:	Get full text
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Summary:	Advances in technology have correlated with expanding prenatal genetic testing options for pregnant people. Leading medical organizations recommend cell-free DNA as the most sensitive screening test for trisomies 13, 18, and 21, as well as for fetal sex chromosome aneuploidies. The commercially available testing options go beyond these recommended tests, and prenatal care professionals should be familiar with the tests that their patients may choose despite being beyond the scope of current medical recommendations. This article explains updates in cell-free DNA technology and clinical considerations for prenatal care professionals, recognizing that this is a rapidly changing field of science and health care.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1526-9523 1542-2011 1542-2011
DOI:	10.1111/jmwh.13674