Oxysulfonylation of Alkynes with Sodium Sulfinates to Access β-Keto Sulfones Catalyzed by BF3·OEt2

Oxysulfonylation of Alkynes with Sodium Sulfinates to Access β-Keto Sulfones Catalyzed by BF3·OEt2

An efficient and operationally simple method for the synthesis of β-keto sulfones through the BF3·OEt2-promoted reaction of alkynes and sodium sulfinates is developed. With its facile and selective access to the targets, it features good functional group compatibility, mild conditions, easily availa...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 29; no. 15; p. 3559
Main Authors: Yu, Shi-Wei, Chen, Zu-Jia, Li, Huan-Qing, Li, Wen-Xi, Li, Yun, Li, Zong, Wang, Zhao-Yang
Format: Journal Article
Language:English
Published: Basel MDPI AG 28-07-2024
Subjects:
alkynes
BF3·OEt2
Chemistry
Free radicals
Investigations
Reagents
Sodium
sodium sulfinates
Solvents
sulfonylation reaction
Sulfur
β-Keto sulfones
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Summary:An efficient and operationally simple method for the synthesis of β-keto sulfones through the BF3·OEt2-promoted reaction of alkynes and sodium sulfinates is developed. With its facile and selective access to the targets, it features good functional group compatibility, mild conditions, easily available starting materials, and good yields. Notably, the reaction does not require metal catalysts or chemical reagents with pungent odors.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29153559