independent rescue from apoptosis by stilbene derivatives in rat cardiomyocytes

Apoptosis of rat cardiomyocytes induced by staurosporine is prevented by a stilbene derivative (DIDS), which is a known blocker of both exchangers and Cl − channels. To clarify its target, staurosporine‐induced activation of caspase‐3, DNA laddering and cell death were examined in cultured rat cardi...

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Bibliographic Details
Published in:	FEBS letters Vol. 579; no. 2; pp. 517 - 522
Main Authors:	Tanabe, Shigeru, Wang, Xiaoming, Takahashi, Nobuyuki, Uramoto, Hiromi, Okada, Yasunobu
Format:	Journal Article
Language:	English
Published:	17-01-2005
Online Access:	Get full text
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Summary:	Apoptosis of rat cardiomyocytes induced by staurosporine is prevented by a stilbene derivative (DIDS), which is a known blocker of both exchangers and Cl − channels. To clarify its target, staurosporine‐induced activation of caspase‐3, DNA laddering and cell death were examined in cultured rat cardiomyocytes. Removal of ambient , which minimizes the function of exchangers, failed to affect the preventive effect of DIDS on apoptosis. A carboxylate analog Cl − channel blocker, which does not block exchangers, also inhibited apoptotic events. Thus, rescue by DIDS of cardiomyocytes from apoptosis is mediated by blockage of Cl − channels.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/j.febslet.2004.12.020