EXPLORING THE INFLUENCE OF NEUTROPHIL-LYMPHOCYTE RATIO ON OUTCOME PREDICTION OF SEVERELY-ILL PATIENTS WITH COVID-19

• Published in: Wiadomości lekarskie (1960) Vol. 75; no. 12; p. 2926
• Main Authors: Abeid, Samir Taha, Mezedawee, Ameer Ali Suker, Alam, Yasir Salah Jumah
• Format: Journal Article
• Language: English
• Published: Poland 2022
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; COVID-19; Humans; Lymphocytes - metabolism; Middle Aged; Neutrophils - metabolism; Prognosis; Retrospective Studies; ROC Curve; SARS-CoV-2; Young Adult; COVID-19; D-dimer; NLR; prognosis
• ISSN: 0043-5147
• DOI: 10.36740/WLek202212106

The aim: The study conducted to have a better understanding on the role of neutrophil-lymphocyte ratio in the determination of the prognosis of COVID-19 and to assist in predicting disease severity.
Materials and methods: A total of 96 patients within age group 18-80 years who were verified positive for the COVID-19 by PCR, and admitted to (Al-Sader Medical City) in Al-Najaf City between (July to October 2020) were enrolled in a cohort retrospective study, Neutrophil to lymphocyte ratio was calculated via taking the absolute neutrophil count divided by the absolute lymphocyte count. Other parameters like (renal function tests, D-dimer, C-reactive protein, serum ferritin) also has been studied in relation to outcome of patients with COVID-19.
Results: The Neutrophil-lymphocyte ratio was significantly associated with low oxygen saturation and poor outcome. A significant difference was found between two clusters in CRP, serum ferritin, and D-dimer level. In addition, age and obstructive airway disease were important clinical predictors for poor outcome.
Conclusions: The study was a useful prognostic marker linked with poor outcome in patients admitted for COVID-19 pneumonia. Other inflammatory markers, such as ferritin, CRP, and D-dimer were also associated with critical illness and increased mortality from COVID-19 disease.