First-Genome Sequence Data of an Alcaligenes nematophilus Strain EBU-23 Encoding bla Gene Implicated in Acute Childhood Gastroenteritis

Although an environmental contaminant, Alcaligenes sp. are now increasingly reported in clinical infections. Here, we present a whole-genome sequence of an extended spectrum beta-lactamase (ESBL) Alcaligenes nematophilus strain EBU-23 encoding beta-lactamase, bla gene, isolated from the stool of a h...

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Bibliographic Details
Published in:	Current microbiology Vol. 81; no. 12; p. 436
Main Authors:	David, Ebuka Elijah, Igwenyi, Ikechuku Okorie, Iroha, Ifeanyichukwu Romanus, Martins, Layla Farage, Uceda-Campos, Guillermo, da Silva, Aline Maria
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-12-2024 Springer Nature B.V
Subjects:	Alcaligenes Alcaligenes - genetics Alcaligenes - isolation & purification Amides Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial agents Bacteria beta-Lactamases - genetics Biochemistry Biomedical and Life Sciences Biotechnology Cephalosporins Children Contaminants Drug resistance Drug Resistance, Multiple, Bacterial - genetics Efflux Enzymes Feces - microbiology Fluoroquinolones Gastroenteritis Gastroenteritis - microbiology Gastroenteritis - parasitology Genes Genome, Bacterial Genomes Genomic analysis Hospitalization Humans Infant Laboratories Life Sciences Microbial Sensitivity Tests Microbiology Multidrug resistance Multidrug resistant organisms Nigeria Nucleotide sequence Pathogens Penicillin Permease Proteins Short Communication Whole Genome Sequencing β Lactamase β-Lactam antibiotics Nigeria
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Summary:	Although an environmental contaminant, Alcaligenes sp. are now increasingly reported in clinical infections. Here, we present a whole-genome sequence of an extended spectrum beta-lactamase (ESBL) Alcaligenes nematophilus strain EBU-23 encoding beta-lactamase, bla gene, isolated from the stool of a hospitalized infant with acute gastroenteritis in a tertiary hospital in Nigeria. Antibiotics susceptibility test revealed that the isolate was resistant to the β-lactams, cephalosporins, and penicillin, β-lactam combination, and the fluoroquinolones. Genomic analysis exposed the presence of a class A beta-lactam hydrolase gene and multiple multidrug efflux permease which may be responsible for the beta-lactamase and multidrug resistance observed with the isolate. To the best our knowledge, we describe the first whole-genome sequence of a multidrug-resistant A. nematophilus implicated in acute childhood gastroenteritis in Nigeria.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0343-8651 1432-0991 1432-0991
DOI:	10.1007/s00284-024-03966-5