Effect of Cadherin-11 Expression on the Prognosis of a Newly Diagnosed Primary Glioblastoma

• Published in: Brain tumor research and treatment Vol. 9; no. 2; pp. 63 - 69
• Main Authors: Seo, Hyunwoo, Lee, Hye Won, Yoon, Sang-Youl, Chang, Sung Hyun, Park, Seong-Hyun, Hwang, Jeong-Hyun, Park, Tae In, Park, Ki-Su
• Format: Journal Article
• Language: English
• Published: The Korean Brain Tumor Society; The Korean Society for Neuro-Oncology; The Korean Society for Pediatric Neuro-Oncology 01-10-2021; 대한뇌종양학회
• Subjects: Original; 신경외과학
• ISSN: 2288-2405; 2288-2413
• DOI: 10.14791/btrt.2021.9.e16

BACKGROUNDCadherin-11, a cell-to-cell adhesion molecule, is associated with higher tumor grade and decreased patient survival. The purpose of this study was to investigate the clinical significance of cadherin-11 expression in the progression and prognosis of a newly diagnosed primary glioblastoma (GBL). METHODSBetween 2007 and 2016, 52 out of 178 patients diagnosed with a GBL and satisfied the following criteria: 1) a new primary GBL, 2) gross-total resection, 3) immunohistochemically-available tissue, and 4) standardized adjuvant treatment. RESULTSIn terms of staining intensity, the low-intensity cadherin-11 group showed longer progression-free survival (PFS) than the high-intensity cadherin-11 group (median PFS, 12.0 months [95% CI, 11.1-12.9] vs. median PFS, 6.0 months [95% CI, 3.7-8.3]; p<0.001). The low-intensity cadherin-11 group revealed longer overall survival (OS) than the high-intensity cadherin-11 group (median OS, 20.0 months [95% CI, 11.8-16.6] vs. median OS, 15.0 months [95% CI, 11.8-18.2]; p=0.003). The staining intensity of cadherin-11 was a statistically significant factor in PFS and OS in terms of univariate and multivariate analyses (univariate analysis: p<0.001 and p=0.005; multivariate analysis: p<0.001 and p=0.005). CONCLUSIONOur clinical study demonstrates high cadherin-11 expression may be associated with poor PFS and OS for a newly diagnosed primary GBL.