Kallikrein-kinin system and adenosine metabolism system of blood and heart and their changes at hypothalamic-hypophyseal stimulation in rabbits of different age

It was shown that kallikreinogen content was decreased in blood of old rabbits, kallikrein activity was somewhat increased, kininase activity was significantly decreased. In old animals, adenosine metabolism was activated, this being evident from the rise of 5'-nucleotidase and adenosine deamin...

Full description

Saved in:

Bibliographic Details
Published in:	Gerontology (Basel) Vol. 26; no. 5; p. 254
Main Authors:	Frolkis, V V, Frolkis, R A, Pugach, B V, Gunina, L M, Rushkevich, Y E
Format:	Journal Article
Language:	English
Published:	Switzerland 1980
Subjects:	Adenosine - blood Adenosine Deaminase - blood Aging Animals Arginine Vasopressin - pharmacology Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology Kallikreins - blood Kininogens - blood Kinins - blood Myocardium - enzymology Nucleotidases - blood Rabbits
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	It was shown that kallikreinogen content was decreased in blood of old rabbits, kallikrein activity was somewhat increased, kininase activity was significantly decreased. In old animals, adenosine metabolism was activated, this being evident from the rise of 5'-nucleotidase and adenosine deaminase activity in blood and myocardium. Hypothalamic stimulation resulted in significant activation of the kallikrein-kinin system and sharp increase of kallikrein activity, the shifts being less marked in old animals than in adults. In adult animals, vasopressin administration elicited more marked activation of the kallikrein-kinin and adenosine metabolism systems.
ISSN:	0304-324X
DOI:	10.1159/000212425