Multistep Solution Phase Synthesis of 1,2-Diarylbenzimidazoles on the Trident™System

• Published in: Journal of Laboratory Automation Vol. 6; no. 4; pp. 56 - 58
• Main Authors: Vo, Lanchi, Yun, Young K., Wright, Peter, Labadie, Jeff, Swienty-Busch, Juergen
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01-08-2001
• ISSN: 2211-0682; 1535-5535; 1540-2452
• DOI: 10.1016/S1535-5535-04-00145-5

High throughput parallel organic synthesis is now a common practice in discovery chemistry research. Argonaut's modular reaction cassette technology is aimed at parallel synthesis of focused small molecule libraries. The Trident™ automated platform has been designed to perform high throughput organic synthesis using this modular reaction cassette under truly inert conditions and in a robust, reproducible manner. This enables one to generate high quality libraries of small molecules and to access chemistry not normally amenable to automation.
Recently we have introduced a Sample Processing Station (SPS), which enhances the upstream and downstream sample handling capabilities of the Trident™ platform. Enhanced software capabilities also provide the Trident™ synthesizer with powerful reaction development and optimization capabilities. Application of this technology in the synthesis of a small library of 1,2-diarylbenzimidazoles using solution-phase chemistry is presented. A number of product purification and isolation protocols using polymer-bound scavengers are discussed.