Clinical profile and pattern of congenital heart disease in infants of diabetic mother and infants of non-diabetic mother at a tertiary care hospital

• Published in: Journal of neonatal-perinatal medicine Vol. 10; no. 4; p. 403
• Main Authors: Begum, Suraiya, Dey, Sanjoy Kumar
• Format: Journal Article
• Language: English
• Published: Netherlands 2017
• Subjects: Cross-Sectional Studies; Cyanosis - etiology; Diabetes Mellitus - diagnosis; Ductus Arteriosus, Patent - complications; Ductus Arteriosus, Patent - diagnostic imaging; Echocardiography; Female; Gestational Age; Heart Defects, Congenital - blood; Heart Defects, Congenital - complications; Heart Defects, Congenital - diagnostic imaging; Heart Murmurs - etiology; Heart Septal Defects, Atrial - complications; Heart Septal Defects, Atrial - diagnostic imaging; Heart Septal Defects, Ventricular - complications; Heart Septal Defects, Ventricular - diagnostic imaging; Humans; Infant, Newborn; Male; Oxygen - blood; Pregnancy; Pregnancy in Diabetics - diagnosis; Prospective Studies; Respiratory Distress Syndrome, Newborn - etiology; Tachycardia - etiology; Tertiary Care Centers; infant of diabetic mother (IDMs); Congenital heart disease; echocardiography
• ISSN: 1878-4429
• DOI: 10.3233/NPM-170176

To assess the clinical manifestations and pattern of congenital heart diseases (CHD) in infants of diabetic mothers (IDMs) and infants of non-diabetic mothers.
A prospective cross sectional study was carried out at tertiary care center over a period of thirty months. All neonates were included in this study if CHD were identified by echocardiography within this study period. Chi-square test and Fisher's exact test were used to compare between groups.
Out of 62 neonates, IDMs and non-IDMs were equal in number, male and female ratio was 3 : 2, and majority were delivered by cesarean section (85.5%). Mean gestational age was 35 weeks, 62.3% were preterm, and 37.7% were term. Common clinical presentations were cardiac murmur (61%), and respiratory distress (43.5%). Less common presentations were low SaO2 (27.4%), tachycardia (24.2%), and cyanosis (24.2%). Common combination of presentations were murmur and tachypnea (38.7%); cyanosis and low SaO2 (24.19%); and low SaO2 and tachypnea 15(24.19). The common echocardiographic findings were atrial septal defect (ASD; 72.6%), patent ductus arteriosus (PDA; 45.2%), and ventricular septal defect (VSD; 25.8%). ASD (77.4% vs 67.7%) and VSD (35.5% vs 16.1%) were more in IDMs, and PDA (48.4% vs 41.9%) was more in non-IDMs. These differences were not significant between groups.
Clinical presentation and echocardiographic findings of CHD were similar in IDMs and non-IDMs.