Dynamic immune status of pregnancy and dermatological diseases: An interplay

• Published in: Clinical dermatology review Vol. 5; no. 2; pp. 131 - 138
• Main Authors: Navya Parthasarathy, Ajit B Janagond, Arun C Inamadar, Anusha Lingaiah, Meghana Gangadhar, Nazneen Zulfikar Arsiwala, Rintu Merin George, Vartika Ratan
• Format: Journal Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 01-07-2021
• Subjects: immune system; leprosy; pregnancy; psoriasis; syphilis; systemic lupus erythematosus; torch infections; varicella
• ISSN: 2542-551X; 2542-5528
• DOI: 10.4103/CDR.CDR_47_19

Dynamic changes of immune system in the various stages of pregnancy affect the course of various diseases afflicting the mother alongside determining how pregnancy affects these diseases. To understand this, a thorough knowledge on how the immune system differs in pregnancy is essential. The complex interplay between the maternal and fetal immune systems via placenta in order to maintain the pregnancy leads to waxing and waning of immune responses in both mother and fetus. This dynamic nature of immune responses can heavily influence the manifestations and severity of several dermatological diseases, whether infectious or noninfectious. Here, we discuss the effect of altered immunity of gestation on a few important dermatological diseases such as psoriasis, systemic lupus erythematosus, syphilis, varicella, leprosy, and TORCH infections and vice versa.