A pH‐Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect (Adv. Mater. 42/2022)

• Published in: Advanced materials (Weinheim) Vol. 34; no. 42
• Main Authors: Cheng, Ruoyu, Jiang, Lingxi, Gao, Han, Liu, Zehua, Mäkilä, Ermei, Wang, Shiqi, Saiding, Qimanguli, Xiang, Lei, Tang, Xiaomei, Shi, Minmin, Liu, Jia, Pang, Libin, Salonen, Jarno, Hirvonen, Jouni, Zhang, Hongbo, Cui, Wenguo, Shen, Baiyong, Santos, Hélder A.
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01-10-2022
• Subjects: Anticancer properties; cancer; Clusters; Hydrophobicity; Materials science; Metal-organic frameworks; Nanoparticles; pH‐responsive targeting; targeting
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.202270290

Tumor Therapy
A pH‐responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co‐workers in article number 2203915, based on acid‐induced conversion from hydrophilicity to hydrophobicity, leading to aggregated nanoparticles. These nanoparticles inhibit tumor growth and reactivate the tumor microenvironment in both pancreatic and breast cancer models.