Follow-Up After Pulmonary Valve Replacement in Adults With Tetralogy of Fallot

• Published in: Journal of the American College of Cardiology Vol. 56; no. 18; pp. 1486 - 1492
• Main Authors: Scherptong, Roderick W.C., MD, Hazekamp, Mark G., MD, PhD, Mulder, Barbara J.M., MD, PhD, Wijers, Olivier, MSc, Swenne, Cees A., PhD, van der Wall, Ernst E., MD, PhD, Schalij, Martin J., MD, PhD, Vliegen, Hubert W., MD, PhD
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 26-10-2010
• Subjects: Cardiovascular; electrocardiography; Internal Medicine; outcome; pulmonary valve replacement; QRS duration; tetralogy of Fallot; NYHA; pulmonary artery; PR; pulmonary regurgitation; RV; right ventricular; CI; ECG; HR; TOF; pulmonary valve replacement; tetralogy of Fallot; PVR; electrocardiography; RVOT; right ventricular outflow tract; New York Heart Association; PA; electrocardiogram; hazard ratio; QRS duration; confidence interval; outcome
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2010.04.058

Objectives The aim of this study was to analyze whether QRS duration, before and after pulmonary valve replacement (PVR), is related to long-term outcome in patients with tetralogy of Fallot (TOF). Background Key factors that determine outcome after PVR in adult TOF patients are largely unknown. Recognition of such factors assists the identification of patients at increased risk of adverse events. Methods Adults who previously underwent total correction for TOF (n = 90; age 31.4 ± 10.3 years) and required PVR for pulmonary regurgitation were included. The QRS duration was measured pre-operatively and 6 months after PVR. The post-operative changes in QRS duration were calculated. Adverse events (death, re-PVR, ventricular tachycardia, and symptomatic heart failure) were noted during follow-up. Results During 5.5 ± 3.5 years of follow-up, 13 adverse events occurred. The 5-year event-free survival rate was 76% for patients with a pre-operative QRS duration >180 ms and 90% in patients with a QRS duration ≤180 ms (p = 0.037). For patients with a post-operative QRS duration >180 ms, 5-year event-free survival was 71%, whereas it was 91% for patients with a post-operative QRS duration ≤180 ms (p = 0.004). After multivariate correction, a post-operative QRS duration >180 ms (hazard ratio: 3.685, 95% confidence interval: 1.104 to 12.304, p < 0.05) and the absence of a reduction in QRS duration post-PVR (hazard ratio: 6.767, 95% confidence interval: 1.704 to 26.878, p < 0.01), was significantly associated with adverse outcome. Conclusions Severe QRS prolongation, before or after PVR, and the absence of a reduction in QRS duration after PVR, are major determinants of adverse outcome during long-term follow-up of patients with TOF.