The Effect of Diabetes on the Physiological Parameters in Male Rats

• Published in: Al-Anbar journal of veterinary sciences Vol. 13; no. 1; pp. 66 - 73
• Main Authors: mukhlif, Ziadoon, Rahim, Saleh, jamal, Mustafa
• Format: Journal Article
• Language: English
• Published: College of Veterinary Medicine, University of Fallujah 26-06-2020
• DOI: 10.37940/AJVS.2020.13.1.8
• EISSN: 2707-0603
• ISSN: 1999-6527

The aim of this study is to assess the effects of high blood glucose levels in male rats with diabetic induced by alloxan on their physiological conditions. Diabetes mellitus is a category of metabolic hyperglycemia disorders caused by insufficient body production or pancreatic action. In addition to hyperglycemia, a number of other factors are also important for pathogenesis, such as Hyperlipidemics and cortisol oxidative. Forty five mature male rats used in this study, these were divided into 3 groups, Control group(G1) : gavage distilled water, Group2(G2): injection intraperitoneally with Alloxan150 mg/kg bw for two weeks and Group3(G3): injection intraperitoneally with Alloxan 150mg/kg bw for twenty four days. Blood samples taken from all groups estimation of Peroxynitrate, GSH, CAT, and SOD concentrations%. The findings revealed a significant improvement in diabetic classes in glucose (p<0.05) and peroxynitrate relative to control (G1). Diabetic concentrations of (G2, G3) relative to the control group (G1) were substantially reduced in SOD, GSH, CAT and diabetes mediated (P < 0,05). In conclusion, diabetes can cause significant changes in SOD, GSH, CAT levels in rats.