The Effect of Diabetes on the Physiological Parameters in Male Rats

• Published in: Al-Anbar journal of veterinary sciences Vol. 13; no. 1; pp. 66 - 73
• Main Authors: mukhlif, Ziadoon, Rahim, Saleh, jamal, Mustafa
• Format: Journal Article
• Language: English
• Published: College of Veterinary Medicine, University of Fallujah 26-06-2020
• ISSN: 1999-6527; 2707-0603
• DOI: 10.37940/AJVS.2020.13.1.8

The aim of this study is to assess the effects of high blood glucose levels in male rats with diabetic induced by alloxan on their physiological conditions. Diabetes mellitus is a category of metabolic hyperglycemia disorders caused by insufficient body production or pancreatic action. In addition to hyperglycemia, a number of other factors are also important for pathogenesis, such as Hyperlipidemics and cortisol oxidative. Forty five mature male rats used in this study, these were divided into 3 groups, Control group(G1) : gavage distilled water, Group2(G2): injection intraperitoneally with Alloxan150 mg/kg bw for two weeks and Group3(G3): injection intraperitoneally with Alloxan 150mg/kg bw for twenty four days. Blood samples taken from all groups estimation of Peroxynitrate, GSH, CAT, and SOD concentrations%. The findings revealed a significant improvement in diabetic classes in glucose (p<0.05) and peroxynitrate relative to control (G1). Diabetic concentrations of (G2, G3) relative to the control group (G1) were substantially reduced in SOD, GSH, CAT and diabetes mediated (P < 0,05). In conclusion, diabetes can cause significant changes in SOD, GSH, CAT levels in rats.