Effect of dalfamprine on spatiotemporal gait parameters in multiple sclerosis

• Published in: Annals of physical and rehabilitation medicine Vol. 58; pp. e104 - e105
• Main Authors: Abadie, L, Guyot, M.A, Khenioui, H., Dr, Agnani, O, Hautecoeur, P., Prof, Donze, C., Dr
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01-09-2015
• Subjects: Dalfampridine; Gait analysis; Internal Medicine; Multiple slerosis; Physical Medicine and Rehabilitation; Spatiotemporal gait parameters; Dalfampridine; Multiple slerosis; Spatiotemporal gait parameters; Gait analysis
• ISSN: 1877-0657; 1877-0665
• DOI: 10.1016/j.rehab.2015.07.253

Objective Improvement of spatiotemporal gait parameters with dalfampridine. Method Retrospective study of data collected prospectively in patients with multiple sclerosis treated by dalfampridine for gait disorders. Spatiotemporal gait parameters [1] were measured using a locometer at spontaneous and supported velocity after the establishment of dalfambridine and after 14 days of treatment. In addition, a clinical examination and Time 25 Foot Walk Test (T25FW) were executed. Results Two hundred patients with dalfampridine were evaluated between April 2013 and September 2014. Eighty-six patients had exploitable gait analysis (age: 53.3 ± 9.5; median EDSS: 5.5 [max: 6.5; min: 4]). Forty-one (47.6%) were classified as responders (R) to the dalfampridine after improving their T25FWT of over 20% and 45 (52.3%) as non-responders (NR). The dalfampridine improved the spontaneous and supported walking velocity in the 2 groups ( P < 0.05). The cadence and stride length improved in the 2 groups independently of the velocity ( P < 0.05). On D14, the NR became asymmetrical ( P < 0.001) in spontaneous velocity. There was an inverse correlation between spontaneous walking velocity to D0 and the % of improvement T25FWT ( r = –0.524; P < 0.0001). Discussion Dalfampridine improves some spatiotemporal gait parameters in R as in NR but NR become asymmetrical at spontaneous velocity. The lack of improvement in voluntary motor function could explain this asymmetry. Spontaneous walking speed measured with locometer could be a predictive factor of response to dalfampridine.