Pharmacological priapism: comparison of trazodone- and papaverine-associated cases

Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine. Trazodone-related priapism uniformly required surgical procedures and resulted in impotence in two of three cases. In contrast, papaverine-associated priapism was successfully managed by...

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Bibliographic Details
Published in:	International urology and nephrology Vol. 22; no. 2; pp. 147 - 152
Main Authors:	Bardin, E D, Krieger, J N
Format:	Journal Article
Language:	English
Published:	Netherlands 01-03-1990
Subjects:	Depressive Disorder - drug therapy Erectile Dysfunction - drug therapy Humans Male Papaverine - adverse effects Papaverine - therapeutic use Priapism - chemically induced Priapism - therapy Trazodone - adverse effects Trazodone - therapeutic use
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Summary:	Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine. Trazodone-related priapism uniformly required surgical procedures and resulted in impotence in two of three cases. In contrast, papaverine-associated priapism was successfully managed by aspiration and all seven patients continued to respond to intracorporal treatment. Iatrogenic priapism is an important complication of therapy with vasoactive drugs.
ISSN:	0301-1623 1573-2584
DOI:	10.1007/BF02549833