Angioedema and Urticaria Associated with Fluoxetine in a Preadolescent Boy

• Published in: Cocuk Acil ve Yogun Bakım Vol. 5; no. 3; pp. 144 - 146
• Main Authors: Sürer Adanır, Aslı, Önder, Arif, Soğucak, Zehra Ece, Başaran, Abdurrahman Erdem, Bingöl, Ayşen, Özatalay, Esin
• Format: Journal Article
• Language: English
• Published: Istanbul Çocuk Acil Tıp ve Yoğun Bakım Derneği 01-12-2018; Galenos Publishing House; Galenos Yayinevi
• Subjects: Adverse effect; Angioedema; Antidepressants; child; Edema; fluoxetine; Permeability; Skin; Tıp; Urticaria; Türkiye; Adana; angioedema; fluoxetine; ürtiker; fluoksetin; yan etki; urticaria; Anjiyoödem; çocuk; Adverse effect; child
• ISSN: 2146-2399; 2148-7332; 2717-9206
• DOI: 10.4274/cayd.63935

Angioedema is defined as increased permeability and dilatation of
the capillaries in the deep dermis or subcutaneous or submucosal
tissues leading to localized swelling, often affecting the upper
respiratory and gastrointestinal tracts. It can also be observed as
a rare adverse effect of selective serotonin reuptake inhibitors, as
is the case with many other drugs. Here, we report a 10-year-old
boy who had urticaria with fluoxetine use, showed recovery after
cessation of the drug, and manifested with urticaria and angioedema
after re-prescription. In the literature, there are two previous case
reports of angioedema with fluoxetine. One case of angioedema
accompanied by urticaria and showed a flu-like presentation 2 days
after ingestion of high-dose fluoxetine. The other case, reporting
angioedema with 10 mg/day, was without urticaria and thought to
be a pseudoallergic reaction. We assume that our case is unique in
this respect for that angioedema developed with therapeutic doses
and thought to be allergic.