The atorvastatin effects on the prevention of contrast-induced acute kidney injury during computed tomography with contrast media

• Published in: Terapevtic̆eskii arhiv Vol. 94; no. 9; pp. 1057 - 1061
• Main Authors: Vasin, Andrey A., Mironova, Olga Iu, Fomin, Victor V.
• Format: Journal Article
• Language: English; Russian
• Published: "Consilium Medicum" Publishing house 24-10-2022
• Subjects: cardiovascular disease; computed tomography; contrast media; contrast-associated acute kidney injury; contrast-induced acute kidney injury; contrast-induced nephropathy
• ISSN: 0040-3660; 2309-5342
• DOI: 10.26442/0403660.2022.09.201845

Aim. To assess the role of atorvastatin to the frequency of contrast-induced acute kidney injury (CI-AKI) in patients with cardiovascular diseases (CVD) undergoing computed tomography (CT) with intravenous contrast media.
Materials and methods. One hundred patients with CVD undergoing CT with with intravenous contrast media administration were included in prospective observational study (ClinicalTrials.gov ID NCT04666389). Patients were divided into 3 groups 16 (15.8%) patients receiving atorvastatin at a dose of 80 mg 24 hours and 40 mg before the CT and 40 mg after; 33 (32.7%) patients 40 mg before the CT and 40 mg after; 52 (51.5%) people not receiving statin therapy. The primary endpoint was CI-AKI according to KDIGO criteria: the 25% rise (or 0.5 mg/dl) of serum creatinine from baseline assessed 4872 hours after administration of contrast media. There were 51% of men. The average age was 59.7714.4. The most frequent cardiovascular disease was hypertension 86%.
Results. CI-AKI was diagnosed in 4 (3.96%) patients. At the same time, it was not possible to establish statistically significant relationships (p0.05) between risk factors and the development of CI-AKI. Statins can be a successful way to prevent this complication.
Conclusion. Cardiovascular diseases may increase the risk of CI-AKI after computed tomography with intravenous contrast media administration. Therefore, it is recommended to evaluate the serum creatinine concentration in such patients.