Green synthesis of nano zero-valent iron doped on bimetallic Ti/Mo-MOF for highly sensitive Peroxidase like colorimetric detection of Cholesterol and antioxidant/antimicrobial efficiencies

• Published in: Physica scripta Vol. 99; no. 7; pp. 75985 - 75999
• Main Authors: Syed, Asad, Badraldin, Sarah Qutayba, Bahkali, Ali H, Mohammed, Sami, Athab, Ayat H, Wang, Shifa, Wong, Ling Shing, Fallah Amer, Ramadan, Janani, Baadal Jushi
• Format: Journal Article
• Language: English
• Published: IOP Publishing 01-07-2024
• Subjects: antibacterial; antifungal; antioxidant; MOF; peroxidase activity; red cabbage
• ISSN: 0031-8949; 1402-4896
• DOI: 10.1088/1402-4896/ad579e

In this research paper, we report a clean and simple approach for the phytosynthesis of nanoparticles zero-valent iron (nZVI) through the in situ reduction of Fe 2+ to Fe 0 using red cabbage extract. These nZVI were then loaded onto a Ti/Mo-MOF nanostructure, resulting in the formation of a novel nZVI@Ti/Mo-MOF nanocomposite. To synthesize the nanoparticles zero-valent iron, we utilized red cabbage extract as a reducing agent. Subsequently, the synthesized nanoparticles zero-valent iron were incorporated into a Ti/Mo-MOF to create the nZVI@Ti/Mo-MOF nanocomposite. The characterization of the biosynthesized nZVI@Ti/Mo-MOF nanocomposite was conducted using UV–vis spectroscopy, FT-IR, XRD, XPS, FESEM, and EDS. The nZVI@Ti/Mo-MOF nanocomposite was used to sensitive peroxidase colorimetric sensing of cholesterol. Under optimal conditions, the cholesterol concentration range was investigated from 1.0 nM to 100.0 nM, which that show a linear relationship with detection response. The detection limit of the nZVI@Ti/Mo-MOF sensor is 6.24 nM. Furthermore, we investigated the antioxidant properties and antimicrobial activity of the nZVI@Ti/Mo-MOF nanocomposite and its constituents against four bacterial strains as well as two fungal strains. Additionally, the nanocomposite demonstrated superior antioxidant properties compared to other synthesized compounds and paves a way for manufacturing innovation.