Intracranial menigioma manifested after delivery in a patient with Hodgkin's disease

• Published in: Vojnosanitetski pregled Vol. 63; no. 3; pp. 305 - 308
• Main Authors: Nagulic, Mirjana, Tukic, Ljiljana, Ilic, Srbislav, Markovic, Marko
• Format: Journal Article
• Language: English; Serbian
• Published: Serbia Military Health Department, Ministry of Defance, Serbia 01-03-2006
• Subjects: Adult; Female; Hodgkin disease; Hodgkin Disease - therapy; Humans; Meningeal Neoplasms - diagnosis; meningioma; Meningioma - diagnosis; Neoplasms, Second Primary - diagnosis; neurosurgical procedures; parturition; Pregnancy; Pregnancy Complications, Neoplastic; remission induction
• ISSN: 0042-8450; 2406-0720
• DOI: 10.2298/VSP0603305N

Intracranial meningioma is rerely reported in the patients treated for Hodgkin's disease (HD), known to mainly occur in the area of radiation therapy.
A 26-year-old woman with HD, and intracranial meningioma following the delivery, was presented. As we knew, a similar case had not been reported in the literature before. Three years prior the surgery for intracranial tumor, the patient had been started to be treated for HD of neoplasm stage I (NS I) type, by the use of the standard (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) BEA-COPP protocol. The remission of HD, achieved after 7 cycles, persisted over a 27-month-period up to the delivery. Within this period, the patient was without neurologic disorder, but with the obvious psychotic behavior, for which the patient was treated with haloperidol. Two days following the normal delivery, during the acute disorder of the consciousness, intracranial tumor was found. A complete bilateral meningioma (11.7 x 8.3 x 8.1 cm) of the frontal parietal zone was removed.
there were no reliable signs of the use of an intensive hemotherapy in the reported case (alkylating cytostatics and topoisomerases inhibitors) which might have caused the proliferation of a benign solid tumor. The pregnancy was supposed to be the possible second risk factor for causing the growth of a meningioma. On the basis of the significant psychic disorders before the pregnancy, as well as upon the size of the operated on tumor, we concluded that the occurrence of intracranial meningioma could be regarded the parallel neoplastic disease or the second primary tumor.