Resistance of mice to secondary infection with Schistosoma mansoni. I. Comparison of bisexual and unisexual initial infections

Resistance of mice to secondary infection with Schistosoma mansoni. I. Comparison of bisexual and unisexual initial infections

Mice receiving a unisexual primary infection with either sex of Schistosoma mansoni did not develop detectable resistance to reinfection. In contrast, mice receiving a bisexual primary infection developed a high degree of resistance. The number of adult worms developing from the challenge infection...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene Vol. 27; no. 5; p. 951
Main Authors: Dean, D A, Minard, P, Stirewalt, M A, Vannier, W E, Murrell, K D
Format: Journal Article
Language:English
Published: United States 01-09-1978
Subjects:
Animals
Biomphalaria - parasitology
Disease Models, Animal
Female
Humans
Male
Mice
Schistosoma mansoni - growth & development
Schistosoma mansoni - immunology
Schistosomiasis - immunology
Schistosomiasis - parasitology
Sex Factors
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Summary:Mice receiving a unisexual primary infection with either sex of Schistosoma mansoni did not develop detectable resistance to reinfection. In contrast, mice receiving a bisexual primary infection developed a high degree of resistance. The number of adult worms developing from the challenge infection was reduced, relative to controls, by 72--100% at challenge times of 6 weeks or greater.
ISSN:0002-9637
DOI:10.4269/ajtmh.1978.27.951