Evaluation of [ 11C]MRB for receptor occupancy studies of norepinephrine transporters

Results As previously reported (Logan et al., 2005), [C-11]MRB VT estimates in anaesthetized monkeys are too variable from scan to scan, and BPND values cannot be computed. [...]only the relative distribution volume (DVR) was used to estimate ATX IC50.

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Bibliographic Details
Published in:	NeuroImage (Orlando, Fla.) Vol. 41; p. T49
Main Authors:	Gallezot, Jean- Dominique, Weinzimmer, D., Nabulsi, N., Lin, S- F., Fowles, K., Maguire, P., Carson, R.E., Ding, Y- S.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 2008 Elsevier Limited
Subjects:	Digital video recorders Drug therapy Plasma Studies
Online Access:	Get full text
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Description
Summary:	Results As previously reported (Logan et al., 2005), [C-11]MRB VT estimates in anaesthetized monkeys are too variable from scan to scan, and BPND values cannot be computed. [...]only the relative distribution volume (DVR) was used to estimate ATX IC50.
ISSN:	1053-8119 1095-9572
DOI:	10.1016/j.neuroimage.2008.04.223