Evaluation of Safety and Immunotoxicity of Immunol, A Polyherbal Formulation in Rats

Evaluation of Safety and Immunotoxicity of Immunol, A Polyherbal Formulation in Rats

Immunol, a polyherbal formulation was evaluated for its safety and effect on the immune system of rats. The rats were administered a single oral dose of 20 mL kg super(-1) b.wt. while others were given repeated doses of 1, 5 and 10 mL kg super(-1) b.wt., orally for 28 days. Immunol treatment did not...

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Published in:Journal of pharmacology & toxicology Vol. 5; no. 6; pp. 262 - 274
Main Authors: Sulaiman, S.M., Rajashekha, Geetha, Prakash, P.J., Singh, D.S., Saleem, C.
Format: Journal Article
Language:English
Published: 01-10-2010
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Abstract Immunol, a polyherbal formulation was evaluated for its safety and effect on the immune system of rats. The rats were administered a single oral dose of 20 mL kg super(-1) b.wt. while others were given repeated doses of 1, 5 and 10 mL kg super(-1) b.wt., orally for 28 days. Immunol treatment did not elicit any abnormalities on the body weight gain, food consumption, neurological assessment, hematology and clinical chemistry parameters, organ weights, gross organ pathology and histopathology and humoral immunity, but it enhanced the cell mediated immunity. It was concluded that Immunol was safe at single oral dose of 20 mL kg super(-1) b.wt. and repeated dose of 10 mL kg super(-1) b.wt. in rats for 28 days.
AbstractList Immunol, a polyherbal formulation was evaluated for its safety and effect on the immune system of rats. The rats were administered a single oral dose of 20 mL kg super(-1) b.wt. while others were given repeated doses of 1, 5 and 10 mL kg super(-1) b.wt., orally for 28 days. Immunol treatment did not elicit any abnormalities on the body weight gain, food consumption, neurological assessment, hematology and clinical chemistry parameters, organ weights, gross organ pathology and histopathology and humoral immunity, but it enhanced the cell mediated immunity. It was concluded that Immunol was safe at single oral dose of 20 mL kg super(-1) b.wt. and repeated dose of 10 mL kg super(-1) b.wt. in rats for 28 days.
Author Prakash, P.J.
Rajashekha, Geetha
Sulaiman, S.M.
Saleem, C.
Singh, D.S.
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CitedBy_id crossref_primary_10_3923_jpt_2012_199_205
Cites_doi 10.3923/jpt.2008.335.343
10.3923/jpt.2008.324.329
10.1016/j.jep.2007.01.010
10.1002/ptr.996
10.1016/0378-8741(95)01318-0
10.3923/jpt.2007.743.747
10.3923/ijp.2008.388.392
10.3923/jpt.2008.134.140
10.3923/jpt.2008.330.334
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