Evaluation of Safety and Immunotoxicity of Immunol, A Polyherbal Formulation in Rats
Immunol, a polyherbal formulation was evaluated for its safety and effect on the immune system of rats. The rats were administered a single oral dose of 20 mL kg super(-1) b.wt. while others were given repeated doses of 1, 5 and 10 mL kg super(-1) b.wt., orally for 28 days. Immunol treatment did not...
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| Published in: | Journal of pharmacology & toxicology Vol. 5; no. 6; pp. 262 - 274 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
01-10-2010
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| Online Access: | Get full text |
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| Summary: | Immunol, a polyherbal formulation was evaluated for its safety and effect on the immune system of rats. The rats were administered a single oral dose of 20 mL kg super(-1) b.wt. while others were given repeated doses of 1, 5 and 10 mL kg super(-1) b.wt., orally for 28 days. Immunol treatment did not elicit any abnormalities on the body weight gain, food consumption, neurological assessment, hematology and clinical chemistry parameters, organ weights, gross organ pathology and histopathology and humoral immunity, but it enhanced the cell mediated immunity. It was concluded that Immunol was safe at single oral dose of 20 mL kg super(-1) b.wt. and repeated dose of 10 mL kg super(-1) b.wt. in rats for 28 days. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| ISSN: | 1816-496X |
| DOI: | 10.3923/jpt.2010.262.274 |