New core configuration for the fabrication of 125I radioactive sources for cancer treatment

• Published in: Applied radiation and isotopes Vol. 165; p. 109307
• Main Authors: Daruich de Souza, Carla, Alberto Zeituni, Carlos, Feher, Anselmo, Augusto Moura, João, Luiz da Costa, Osvaldo, Angelocci, Lucas Verdi, Rostelato, Maria Elisa C.M.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-11-2020
• Subjects: Brachytherapy; Iodine-125 seed core; Monte Carlo simulation; Radiation chemistry; Iodine-125 seed core; Radiation chemistry; Brachytherapy; Monte Carlo simulation
• ISSN: 0969-8043; 1872-9800
• DOI: 10.1016/j.apradiso.2020.109307

In order to provide prostate brachytherapy treatment for more Brazilian men, IPEN is building a laboratory for the manufacture of radioactive sources. The new methodology for the production of iodine-125 seeds with yield 71.7% ± 5.3%. Points of importance were evaluated/discussed: photo-sensibility, reaction vial type, the substitution for iodine-131, pH, and solution volume. The surface was analyzed by FTIR and EDS. At the end, a Monte Carlo-MCNP6 simulation was performed to evaluate the TG-43 parameters.
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•IPEN is building a laboratory for manufacturing radioactive iodine-125 sources.•Silver modification reaction using sodium thiosulfate is presented.•The modifications in the silver core were investigated by SEM, EDS and FT-IR.•Successful modification lead to a 63.70% iodine-125 intake increase.•Monte Carlo analysis was performed.