Studies on a novel oxo-vanadium(V) complex of a tridentate ONO Schiff base ligand: Synthesis, characterization, X-ray crystal structure, Hirshfeld surface analysis, biological and catalytic activity

• Published in: Journal of molecular structure Vol. 1321; p. 139923
• Main Authors: Ebrahimipour, S. Yousef, Nejad, Fatemeh Khajoee, Khosravan, Mehrji, Castro, Jesus, White, Jonathan M., Mohammadi, Pourya, Mohamadi-Nejad, Ghasem, Mohamadi, Maryam
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 05-02-2025
• Subjects: Antibacterial activity; Crystal structure analysis; Glucose oxidation catalyst; Oxovanadium(V) complex; Schiff base ligand; Schiff base ligand; Oxovanadium(V) complex; Antibacterial activity; Crystal structure analysis; Glucose oxidation catalyst
• ISSN: 0022-2860
• DOI: 10.1016/j.molstruc.2024.139923

•Various techniques like X-ray diffraction verified the complex's structure, revealing an octahedral geometry around the vanadium center with specific coordinating groups.•The newly synthesized complex demonstrated impressive catalytic ability for oxidizing glucose under mild conditions, achieving a high conversion rate.•The study investigated the antibacterial activity of both the ligand and the complex against different bacterial strains.•The findings suggest this novel complex could hold promise for applications in catalysis and antibacterial treatments.
This study reports the successful synthesis and characterization of a novel oxovanadium(V) complex, [VO(L)(MeOH)(MeO)], prepared from 2-hydroxy-3-methoxybenzaldehyde and 2-methyl-3-aminoquinazoline. To elucidate the structure of the complex, we employed comprehensive characterization techniques such as CHN analysis, molar conductivity measurements, FT-IR, 1H NMR, UV-Vis spectroscopy, and single-crystal X-ray diffraction. The X-ray analysis confirmed an octahedral geometry around the V(V) center, coordinated with donor atoms from the deprotonated Schiff base ligand, an oxido group, a methanol molecule, and a methoxy group. Hirshfeld surface analysis was employed to evaluate intermolecular interactions.
Furthermore, the complex exhibited impressively efficient catalytic activity in glucose oxidation under mild conditions (aqueous solution, room temperature, O2 oxidant), achieving a conversion rate of 98 %. Additionally, the antibacterial activity of the ligand and complex against various bacterial strains, including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus cereus, was evaluated. The results demonstrated promising antibacterial potential of the [VO(L)(MeOH)(MeO)] complex, particularly against E. coli, P. aeruginosa, and B. cereus. These findings suggest potential applications of this new oxovanadium(V) complex in both catalysis and antibacterial treatments.