Obstructive sleep apnoea: from respiratory events to coronary microvascular dysfunction

Obstructive sleep apnoea (OSA) is an emerging and independent risk factor for cardiovascular diseases; coronary artery disease (CAD) is higher in OSA patients, even in the absence of other traditional cardiovascular risk factors. There is little evidence to show abnormalities in coronary blood flow...

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Bibliographic Details
Published in:	Acta cardiologica Vol. 73; no. 4; pp. 319 - 324
Main Authors:	Morra, Sofia, Roubille, François
Format:	Journal Article
Language:	English
Published:	England Acta Medica Belgica 01-08-2018
Subjects:	Coronary Artery Disease - etiology Coronary Artery Disease - physiopathology Coronary Circulation - physiology Coronary Vessels - physiopathology Endothelium, Vascular - physiopathology Humans Life Sciences Microcirculation Risk Factors Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - physiopathology Vascular Resistance coronary artery disease coronary flow reserve coronary vascular resistance inflammation myocardial work vascular remodelling Obstructive apnoea coronary blood flow intermittent hypoxaemia
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Summary:	Obstructive sleep apnoea (OSA) is an emerging and independent risk factor for cardiovascular diseases; coronary artery disease (CAD) is higher in OSA patients, even in the absence of other traditional cardiovascular risk factors. There is little evidence to show abnormalities in coronary blood flow (CBF) and disorders in coronary vascular resistance (CVR), occurring during the obstructive respiratory event, suggesting coronary microvascular dysfunction (CMD) as a potential mechanism of ischaemic heart disease (IHD) OSA-as a related consequence.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0001-5385
DOI:	10.1080/00015385.2017.1384183