Navigating the Dynamic Landscape of SARS-CoV-2: The Dual Role of Neutralizing Antibodies, Variability in Responses, and Strategies for Adaptive Pandemic Control

• Published in: COVID Vol. 4; no. 9; pp. 1395 - 1412
• Main Authors: Iyer, Venkatesh Anand, Mohan, Aditi, Kumar, Dharmender, Dahiya, Praveen
• Format: Journal Article
• Language: English
• Published: MDPI AG 01-09-2024
• Subjects: immune escape mechanisms; immune response; neutralizing antibodies; SARS-CoV-2; therapeutic monoclonal antibodies; vaccine-induced immunity
• ISSN: 2673-8112; 2673-8112
• DOI: 10.3390/covid4090100

The global pandemic sparked by the emergence of SARS-CoV-2 and its variants has imposed a substantial burden of morbidity and mortality. Central to the battle against these viral threats is the immune response, with a spotlight on the pivotal role played by neutralizing antibodies. This comprehensive review delves into current research, unravelling the dual functionality of neutralizing antibodies acting as formidable barriers to viral replication and crucial facilitators of adaptive immune memory. Beyond this dual purpose, the review illuminates the nuanced variability characterizing neutralizing antibody responses to SARS-CoV-2. Emphasizing the dynamic nature of these responses, the review advocates for the plausible challenges in targeted therapeutic interventions. This review also attempts to compare various vaccination approaches and their impact on SARS-CoV-2, as well as offer insights into various Omicron variations. Recognizing the ever-evolving viral landscape, this exploration underscores the necessity of flexible approaches to address the diverse challenges posed by SARS-CoV-2 and its variants, contributing valuable insights to the ongoing global efforts in pandemic mitigation and public health safeguarding.