Non-myeloablative Stem Cell Transplantation

• Published in: Kita Kantō igaku (The Kitakanto Medical Journal) Vol. 53; no. 4; pp. 369 - 375
• Main Authors: Saito, Yasuyuki, Matsushima, Takafumi, Yokohama, Akihiko, Saito, Tatsuhiro, Doki, Noriko, Kawamura, Toshihide, Handa, Hiroshi, Maekawa, Izuru, Karasawa, Masamitsu, Tsukamoto, Norifumi, Murakami, Hirokazu, Nojima, Yoshihisa
• Format: Journal Article
• Language: English
• Published: The Kitakanto Medical Society 2003
• Subjects: bone marrow transplantation; GVHD; GVT; NST; stem cell
• ISSN: 1343-2826; 1881-1191
• DOI: 10.2974/kmj.53.369

Nonmyeloablative stem cell transplantation (NST) have been developed over the past several years. NST is designed to reduce intensity of preparative myeloablation, and to induce graft-versus-tumor (GVT) effect by engraftment of donor T cells. Compared with conventional allogeneic stem cell transplantation, NST provides lower treatment-related mortality. The degree of GVT effect is generally correlated with the degree of the graft-versus-host disease. Through this novel procedure, allogeneic stem cell transplantation can be applied to elderly or clinically ill patients having variable hematologic disorders or solid tumors. Disease-specific studies with longer follow-up are needed to evaluate this potentially promising therapy. Here we review the preliminary clinical results of NST as immunotherapy for hematologic disorders and solid tumors.