Advanced Assessment of Hepatic Choline and Lipid Profiling via Magnetic Resonance Spectroscopy among Young Saudi Women: Unraveling Metabolic Dynamics and Implications for Health

• Published in: International journal of biomedicine Vol. 14; no. 3; pp. 478 - 483
• Main Author: Halima Hawesa
• Format: Journal Article
• Language: English
• Published: International Medical Research and Development Corporation 01-09-2024
• Subjects: choline; lipids; liver; mrs; svs
• ISSN: 2158-0510; 2158-0529
• DOI: 10.21103/Article14(3)_OA15

Background: Choline, a vital nutrient, and lipids play pivotal roles in liver function and overall metabolic homeostasis. Magnetic resonance spectroscopy (MRS) offers a non-invasive and highly sensitive method for assessing hepatic choline and lipid levels in vivo. This study aims to investigate the correlation between liver choline and lipid levels among young Saudi women. Methods and Results: This cross-sectional research explored the relationship between liver choline and fat levels, employing MRS to estimate these levels. A total of 29 healthy female students from the radiological sciences department, aged between 18 and 25 years, participated in the study. MRS scans were conducted using a 1.5 tesla Philips scanner using single volume sequence (SVS). The SVS spectroscopy sequence used in this study indicated the presence of lipid peaks within the frequency range of 0.9-1.2 ppm and choline peaks at 3.2 ppm. The Pearson correlation test revealed a statistically significant association between choline and lipid levels in the liver (r=0.367, P=0.025). Conclusion: Investigating the relationship between liver lipids and choline levels is crucial for understanding liver health, identifying metabolic dysregulation, informing diagnostic and therapeutic strategies, promoting personalized medicine, and advancing scientific research in the field of metabolism and liver diseases.