Influence of immunization with neurospecific proteins and tubulin on learning in rats

• Published in: Neuroscience and behavioral physiology Vol. 16; no. 5; pp. 384 - 388
• Main Authors: Burbaeva, G Sh, Kamenskii, A A, Klyushnik, T P, Ignatov, S A, Zaiko, S D, Androsova, L V
• Format: Journal Article
• Language: English
• Published: United States 01-09-1986
• Subjects: Animals; Antibodies - physiology; Antigens - immunology; Blood-Brain Barrier; Brain - immunology; Conditioning, Classical - physiology; Humans; Learning - physiology; Male; Nerve Tissue Proteins - immunology; Phosphopyruvate Hydratase - immunology; Rats; Tubulin - immunology
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1007/BF01185368

The administration of antibrain antibodies to experimental animals induces stable changes in their behavior and learning processes. These results have been obtained chiefly with antiserum to an extract of total brain proteins or individual brain structures. However, the role of one protein or another in processes of learning and memory can be judged rigorously enough according to the results of experiments with monospecific antisera. Intraventricular injection of monospecific antiserum to S-100 increases the number of errors and the latency of the response during learning in a maze. The authors studied the influence of circulating antibodies against individual brain proteins on the formation of behavioral habits in rats. Such an experimental procedure made it possible to resolve two problems simultaneously: to identify neurospecific proteins capable of influencing the learning of animals and to demonstrate the permeability of the blood-brain barrier to antibodies formed in the process of immunization.