Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns

• Published in: Biomarkers in medicine Vol. 18; no. 15-16; p. 649
• Main Authors: Silva Barbosa, Joycilene da, Meneses, Gdayllon Cavalcante, Castelo, Luan Rebouças, da Silva Júnior, Geraldo Bezerra, Costa Martins, Alice Maria, Francesco Daher, Elizabeth De, Sampaio, Tiago Lima, Oliveira Gomes, Amanda de, Carvalho Dantas, Suzzy Maria, Silva Rebouças, Arthur da, de Lima, Paula Roberta, Lopes, Nicole Coelho, da Silva, Mateus Edson, Rodrigues da Costa, Mac Dionys, Reis Jereissati, Ana Amelia, Ramos, Victoria Queiroz, Gonçalves Machado, Rosângela Pinheiro, Gonçalves Lemes, Romélia Pinheiro
• Format: Journal Article
• Language: English
• Published: England 17-08-2024
• Subjects: Acute-Phase Proteins - urine; Biomarkers - blood; Biomarkers - urine; Cystatin C - blood; Cystatin C - urine; Female; Humans; Infant, Newborn; Infant, Premature - urine; Length of Stay; Lipocalin-2 - blood; Lipocalin-2 - urine; Male; Proto-Oncogene Proteins - blood; Proto-Oncogene Proteins - urine; Sepsis - blood; Sepsis - diagnosis; Sepsis - urine; premature; acute kidney injury; newborns; biomarkers; sepsis
• ISSN: 1752-0371
• DOI: 10.1080/17520363.2024.2377532

To evaluate the urinary biomarkers related to sepsis in preterm newborns (NBs) and to investigate the predictive capacity of these biomarkers for a longer hospital stay.
Serum and urine were collected from 27 healthy NBs, 24 NBs with neonatal infection without sepsis and 11 NBs with sepsis for the measurement of sindecan-1, lipocalin associated with urinary neutrophil gelatinase (uNGAL), urinary cystatin-C (uCysC) and urinary kidney injury molecule-1.
Levels of uNGAL and urinary cystatin-C were elevated in NBs with sepsis and neonatal infection, and uNGAL was significant predictor of hospital stay longer than 30 days (odds ratio: 1.052; 95% CI: 1.012-1.093;
 = 0.01).
uNGAL was associated with sepsis in preterm NBs and was useful to predict extended hospital stay.