Topology-defined bioactive properties of porous Ti-6Al-4V scaffolds produced by laser powder bed fusion

• Published in: Materials letters Vol. 377; p. 137528
• Main Authors: Kiselevskiy, Mikhail V., Anisimova, Natalia Yu, Novruzov, Keryam M., Kapustin, Alexei V., Ryzhkin, Alexander A., Abramova, Marina M., Enikeev, Nariman A.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15-12-2024
• Subjects: Additive manufacturing; Bioactive properties; Porous scaffolds; Ti alloys; Triply periodic minimized surfaces; Bioactive properties; Ti alloys; Porous scaffolds; Additive manufacturing; Triply periodic minimized surfaces
• ISSN: 0167-577X
• DOI: 10.1016/j.matlet.2024.137528

•Porous Ti6Al4V scaffolds with varied design are additively manufactured.•Bioinspired TPMS and a strut models forming porous structures are considered.•Bioactive properties of scaffolds are studied in vitro using multipotent MMSCs.•TPMS models are superior to a strut model by osteoinductive activity.•Sheet Gyroid and Diamond models are promising for developing 3D-printed scaffolds.
The effect of the design of additively printed Ti porous structures on their bioactive properties is elucidated by in vitro testing. 3D-printed scaffolds with pores defined by several bioinspired triply periodic minimal surfaces as well as by a strut model have been engineered. Cell proliferation, angiogenesis and osteogenesis have been studied with the help of multipotent mesenchymal stromal cells. The elementary unit size and pore design can notably modify bioactive properties of porous structures. The models providing maximal bioactive activity of developed scaffolds are discussed.