Age-Related Changes in Heart Rate Variability from the Neonatal Period to Adulthood

• Published in: Doklady. Biochemistry and biophysics
• Main Authors: Grinevich, A A, Chemeris, N K
• Format: Journal Article
• Language: English
• Published: United States 11-10-2024
• Subjects: cardiovascular system; age-related dynamics; heart rate variability; wavelet analysis; Hilbert–Huang method
• ISSN: 1607-6729; 1608-3091; 1608-3091
• DOI: 10.1134/S1607672924600829

The aim of the study was to reveal the patterns of the age-related dynamics of the frequency-dependent regulation of heart rate variability (HRV) based on the analysis of Holter ECG recordings from healthy subjects of four age groups: neonates, one-year-old infants, adolescents, and adults. A wide spectral composition of HRV is shown, consisting of nine Hilbert-Huang modes in the frequency range from 0.0001 to 2 Hz. A decrease in the central frequencies of all modes is shown in the postnatal period with a plateau in adolescence. A rapid progression of systemic humoral regulation of HRV, characterized by a consolidated increase in the amplitudes of the corresponding modes with a plateau in adolescence, is demonstrated. The dome-shaped character of age-related changes in amplitude of modes associated with autonomic control with a maximum in adolescence is shown. The results obtained quantitatively demonstrate age-related consolidated changes in HRV parameters from neonates to adulthood.