Effect of clindamycin on growth and haemolysin production by Escherichia coli

The effect of clindamycin on growth and haemolysin production by four strains of Escherichia coli was tested. Clindamycin MICs were greater than 256 mg/l for all strains. Clindamycin concentrations of 16-256 mg/l significantly inhibited growth, while concentrations from 2-32 mg/l significantly inhib...

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Bibliographic Details
Published in:	Journal of antimicrobial chemotherapy Vol. 12 Suppl C; p. 105
Main Authors:	Boe, N M, Dellinger, E P, Minshew, B H
Format:	Journal Article
Language:	English
Published:	England 01-10-1983
Subjects:	Animals Clindamycin - blood Clindamycin - pharmacology Erythrocytes - drug effects Escherichia coli - drug effects Escherichia coli - growth & development Escherichia coli - metabolism Hemolysin Proteins - biosynthesis In Vitro Techniques Male Microbial Sensitivity Tests Rabbits Rats Rats, Inbred Strains
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Summary:	The effect of clindamycin on growth and haemolysin production by four strains of Escherichia coli was tested. Clindamycin MICs were greater than 256 mg/l for all strains. Clindamycin concentrations of 16-256 mg/l significantly inhibited growth, while concentrations from 2-32 mg/l significantly inhibited haemolysin production. Administration of clindamycin to rats with peritonitis due to haemolytic E. coli reduced mortality. Subinhibitory concentrations of clindamycin can inhibit growth and haemolysin production by E. coli and reduce mortality in an animal model of haemolytic E. coli peritonitis.
ISSN:	0305-7453
DOI:	10.1093/jac/12.suppl_C.105