Synaptophysin Expression by Supraependymal Structures of Rat Brain

• Published in: Cell and tissue biology Vol. 17; no. 5; pp. 517 - 521
• Main Authors: Razenkova, V. A., Kirik, O. V.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-10-2023; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Cell Biology; Central nervous system; Cerebrospinal fluid; Ependymal cells; Fibers; Forebrain; Life Sciences; Localization; Synaptophysin; Tyrosine 3-monooxygenase; Ventricle; synaptophysin; cerebral ventricles; immunohistochemistry; tyrosine hydroxylase
• ISSN: 1990-519X; 1990-5203
• DOI: 10.1134/S1990519X23050115

—
Supraependymal plexus of the brain ventricles is one of the most mysterious structural formations in the central nervous system. Since both the topography of supraependymal elements and their functional significance remain unclear, the aim of this study was to study the distribution of supraependymal structures within the ventricular system of the rat brain with synaptic function associated marker, synaptophysin. Serial sections of Wistar rats forebrain (4–6 months,
n
= 6) were examined using immunohistochemical detection of synaptophysin and tyrosine hydroxylase. It was demonstrated that supraependymal structures form small discrete clusters on the apical surface of ependymocytes, which indicates synaptic contacts. Although catecholaminergic nerve fibers were present on the ventricular surface in all studied zones, it seems that these nerve fibers may not always contain synaptophysin. Thus, it is supposed that the functional purpose of the supraependymal nerve plexus depends on its localization and can be associated both with the regulation of the functional status of ependymal cells and the formation of the cerebrospinal fluid composition and with the formation of interneuronal synaptic communications.