New insight into the control of peptic ulcer by targeting the histamine H 2 receptor

• Published in: Journal of cellular biochemistry Vol. 119; no. 2; pp. 2003 - 2011
• Main Authors: Singh, Vijai, Gohil, Nisarg, Ramírez-García, Robert
• Format: Journal Article
• Language: English
• Published: United States 01-02-2018
• Subjects: docking; cellular network; anti-ulcer drugs; homology modeling; histamine H2 receptor
• ISSN: 0730-2312; 1097-4644
• DOI: 10.1002/jcb.26361

Peptic ulcer disease is one of the major challenges in public health globally and new evidence shows that it can be controlled by targeting the histamine H
receptor (H
R). Recently, a number of H
R antagonists have been synthesized and used to block the action of histamine on the parietal cells in the stomach and decrease the acid production. In this study, we modeled the H
R by homology modeling using the 3-D crystal structure and this model was validated based on free energy and amino acid residues present in the allowed regions of a Ramachandran plot. We used this 3-D model for screening of highly potent drugs using molecular docking. We found cimetidine, cimetex, and famotidine as the most potent drugs based on the binding affinity of drug-protein interactions. We also generated a cellular network for H
R that could be useful for better understanding of cellular mechanism and drug targets. These findings provide a new insight into the development of suitable, specific, and effective anti-ulcer drugs for a most effective treatment of ulcerous diseases.