Biologics Approaches—When, Why, and How?

• Published in: Operative techniques in sports medicine Vol. 32; no. 2; p. 151082
• Main Authors: Stokes, Daniel J., Felan, Nicholas A., McQuivey, Kade S., McGinley, Beau M., Frank, Rachel M.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-06-2024
• Subjects: adipose-derived stem cells; amniotic-derived stem cells; bone marrow aspirate concentrate; hyaluronic acid; microfragmented adipose tissue; orthobiologics; platelet-rich plasma; adipose-derived stem cells; microfragmented adipose tissue; bone marrow aspirate concentrate; orthobiologics; platelet-rich plasma; hyaluronic acid; amniotic-derived stem cells
• ISSN: 1060-1872; 1557-9794
• DOI: 10.1016/j.otsm.2024.151082

Orthobiologics are being investigated to treat a variety of sports medicine pathologies. This article provides an evidence-based approach summarizing currently available options, including viscosupplementation, platelet-rich plasma, bone marrow aspirate concentration, adipose-derived mesenchymal stem cells, and amniotic-derived mesenchymal stem cells. Orthobiologic use in clinical practice necessitates an understanding of the indications, supporting evidence, risks, and benefits. It should maintain a safe, cost-effective, and resource-conscious approach while adhering to regulatory guidelines. This article provides a foundation for understanding when, why, and how to implement orthobiologics.