Association of vitamin D and insulin resistance among the adults with newly detected prediabetes attending in a tertiary care hospital of Bangladesh

• Published in: Bangabandhu Sheikh Mujib Medical University journal Vol. 14; no. 4; pp. 157 - 162
• Main Authors: Khan, Murshed Ahamed, Fariduddin, Md, Selim, Shahjada, Alam, Mohammad Masum, Morshed, Md Shahed, Ghani, Md Habibul
• Format: Journal Article
• Language: English
• Published: Bangabandhu Sheikh Mujib Medical University 14-03-2022
• Subjects: Vitamin D, Prediabetes, Insulin resistance
• ISSN: 2074-2908; 2224-7750
• DOI: 10.3329/bsmmuj.v14i4.56617

Several studies have found an inverse association between vitamin D level and insulin resistance (IR) causing prediabetes and diabetes. So the current study was done to find out the association between serum vitamin D level and IR among adults with prediabetes. This cross-sectional study was carried out in 140 newly detected adults with prediabetes according to ADA 2018 criteria. The 25(OH) D cutoffs to define deficiency and insufficiency were used according to Endocrine Society (USA) criteria, measurement of vitamin D & insulin (fasting) was done by chemiluminescent microparticle immunoassay (CMIA). Data were analyzed using SPSS (version 22.0) and presented as table and figure. P-value ≤0.05 was considered significant. In this study, most of the population was 30 years and above (73%). The Male-female ratio was 1:7, the majority of participants came from urban areas (81%) and it was observed that there was an increasing trend of insulin resistance across increasing severity of vitamin D deficiency though it was not statistically significant (p= 0.74). In conclusion, vitamin-D deficiency/insuffi- ciency is common among individuals with prediabetes in our country, but there were no associ- ation had been found between vitamin D and insulin resistance in individuals with prediabetes BSMMU J 2021; 14(4): 157-162