Ras Guanine Nucleotide Releasing Protein 4 (RasGRP4) Dependent Pathways and Genes that Reversibly Control the Development, Phenotype, and Function of Human Mast Cells (MCs)

Ras Guanine Nucleotide Releasing Protein 4 (RasGRP4) Dependent Pathways and Genes that Reversibly Control the Development, Phenotype, and Function of Human Mast Cells (MCs)

A RasgrP4-defective variant of the human MC line HMC-1 was used to generate stable clones that expressed green fluorescent protein-labeled human RasgrP4 for monitoring the movement of this signaling protein inside MCs before and after exposure to phorbol-12-myristate 13-acetate (PMA), as well as for...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology Vol. 119; no. 1; p. S50
Main Authors: Katsoulotos, G.P, Tanaka, K, Molloy, T.J, Stevens, R.L, Krilis, S.A
Format: Journal Article
Language:English
Published: St. Louis Mosby, Inc 2007
Elsevier Limited
Subjects:
Allergy and Immunology
Gene expression
Genotype & phenotype
Kinases
Proteins
Online Access:Get full text
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Summary:A RasgrP4-defective variant of the human MC line HMC-1 was used to generate stable clones that expressed green fluorescent protein-labeled human RasgrP4 for monitoring the movement of this signaling protein inside MCs before and after exposure to phorbol-12-myristate 13-acetate (PMA), as well as for evaluating the protein's ability to control the development, phenotype, and function of MCs.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2006.11.217