U-21,963, a new antibiotic. I. Discovery and biological activity

A new antibiotic, U-21,963, is produced by a new strain of Trichoderma viride. Antibiotic activity can be demonstrated against both gram-positive and gram-negative bacteria and also against a wide variety of fungi. U-21,963 is not cross-resistant with other commonly used antibiotics. U-21,963 afford...

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Bibliographic Details
Published in:	Applied microbiology Vol. 14; no. 4; pp. 506 - 510
Main Authors:	Pyke, T R, Dietz, A
Format:	Journal Article
Language:	English
Published:	United States 01-07-1966
Subjects:	Anti-Bacterial Agents - pharmacology Culture Media Escherichia coli - drug effects Fungi - drug effects Klebsiella - drug effects Mitosporic Fungi - metabolism Proteus - drug effects Pseudomonas aeruginosa - drug effects Salmonella - drug effects Staphylococcus - drug effects Streptococcus - drug effects
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Summary:	A new antibiotic, U-21,963, is produced by a new strain of Trichoderma viride. Antibiotic activity can be demonstrated against both gram-positive and gram-negative bacteria and also against a wide variety of fungi. U-21,963 is not cross-resistant with other commonly used antibiotics. U-21,963 afforded no protection against Klebsiella pneumoniae, Streptococcus pyogenes, or Staphylococcus aureus when it was injected subcutaneously into mice.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0003-6919
DOI:	10.1128/am.14.4.506-510.1966