Relationships of the Vitamin D and Platelet Indices in Sjögren’s Syndrome

• Published in: Korean journal of clinical laboratory science Vol. 50; no. 4; pp. 484 - 491
• Main Authors: Günay, Nahide Ekici, Buğday, İrfan, Akalın, Tayfun
• Format: Journal Article
• Language: English
• Published: 대한임상검사과학회 31-12-2018
• Subjects: 기타자연과학
• ISSN: 1738-3544; 2288-1662
• DOI: 10.15324/kjcls.2018.50.4.484

Primer Sjögren’s Syndrome (pSS) is an autoimmune/inflammatory illness. The platelet indices (PIs) indicate the inflammatory response and activity/severity of many diseases. A vitamin D deficiency is accompanied by the increased tendency of autoimmune diseases. This study investigated whether the vitamin D levels are related to the altered platelet indices in pSS. A total of 261 individuals were included in this analytical cross-sectional study. The laboratory data of pSS patients were evaluated and the relationship between the PIs and vitamin D status was examined. According to these findings, in patients with pSS, the vitamin D levels were lower than the healthy control group (P＜0.05). The vitamin D levels were negatively associated with PDW (P=0.012), but positively correlated with PCT (P＜0.001). The cut-off point was obtained with receiver operating characteristics (ROC) curves for PDW: 12.53 (AUC 0.921, sensitivity 90%, specificity 85%), for PCT; 0.29 (AUC 0.660, sensitivity 68%, specificity 55%). In multivariate linear regression analysis, the most significant parameters for the effects of PDW are the following: vitamin D (=−0.373; t=−2.626; sig.=0.013) and plateletcrit (=−0.308; t=−2.13; sig.=0.040).
A vitamin D deficiency may be accompanied by changes in PIs in pSS. A higher PDW and lower PCT supports the underlying inflammation, which may be vitamin D related useful parameters to consider in approaching to pSS. KCI Citation Count: 1