Thymoma-Associated Multiorgan Autoimmunity (TAMA) Presenting as a Graft Versus Host Disease-Like Erythroderma

Thymoma-Associated Multiorgan Autoimmunity (TAMA) Presenting as a Graft Versus Host Disease-Like Erythroderma

Thymoma-associated multiorgan autoimmunity (TAMA) is a rare paraneoplastic disorder that presents similarly to graft versus host disease (GVHD). We report a unique case of TAMA presenting as a GVHD-like erythroderma in an elderly male with a history of benign thymoma. Cutaneous histopathological fin...

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Bibliographic Details
Published in:Journal of cutaneous pathology
Main Authors: Hewitt, Noah, Bertus, Brooke, Farmer, William, Kiavash, Katrin, Beatty, Colleen, Powers, Roxann
Format: Journal Article
Language:English
Published: United States 23-10-2024
Subjects:
dermatitis
autoimmunity
thymoma
exfoliative
graft versus host disease
Online Access:Get full text
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Summary:Thymoma-associated multiorgan autoimmunity (TAMA) is a rare paraneoplastic disorder that presents similarly to graft versus host disease (GVHD). We report a unique case of TAMA presenting as a GVHD-like erythroderma in an elderly male with a history of benign thymoma. Cutaneous histopathological findings demonstrated vacuolar interface dermatitis with numerous dyskeratotic keratinocytes, exocytosis of lymphocytes, and a mildly acanthotic epidermis, which can be seen in several different disease processes. Thus, careful consideration of clinical presentation, historical information, laboratory testing, and histopathologic findings led to the correct diagnosis and treatment.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ISSN:0303-6987
1600-0560
1600-0560
DOI:10.1111/cup.14743