Biodegradation of non-porous films after submucoperiosteal implantation on the palate of Beagle dogs

• Published in: Journal of materials science. Materials in medicine Vol. 6; no. 8; pp. 445 - 450
• Main Authors: Leenstra, T. S., Maltha, J. C., Kuijpers-Jagtman, A. M.
• Format: Journal Article
• Language: English
• Published: 01-08-1995
• ISSN: 0957-4530; 1573-4838
• DOI: 10.1007/BF00123368

The aim of this study is to investigate the in vivo behaviour of five different biodegradable films after submucoperiosteal implantation on the palate of Beagle dogs. Non-porous films of poly-(L-lactic) acid ( identical with PLLA), high molecular weight poly-(L-lactic) acid ( identical with HMW-PLLA), poly-(DL-lactic) acid ( identical with PDLLA), poly( epsilon -caprolactone) ( identical with PCL) and a copolymer of poly hydroxybutyrate 80%-hydroxyvalerate 20% ( identical with PHB-co-HV 80/20) were implanted submucoperiostally on the palate of Beagle dogs. After 2, 4, 8 and 12 weeks in situ, the structure of the films and the tissue reactions were studied histologically. In terms of mechanical properties and tissue response, the PHB-co-HV film is the most suitable for use on dogs.