Hepatitis B Virus-Associated Liver Carcinoma: The Role of Iron Metabolism and Its Modulation

• Published in: Journal of viral hepatitis
• Main Authors: Ali, Imran, Muhammad, Shoaib, Naqvi, Syed Shah Zaman Haider, Wei, Lingxi, Yan, Wenqi, Khan, Muhammad Fiaz, Mahmood, Ahmad, Liu, Hong, Shah, Wahid
• Format: Journal Article
• Language: English
• Published: England 24-10-2024
• Subjects: iron metabolism; iron toxicity; serum iron level; HBV; hepatocellular carcinoma
• ISSN: 1352-0504; 1365-2893; 1365-2893
• DOI: 10.1111/jvh.14016

Hepatitis B virus (HBV) infection is a significant contributor to the development of hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality worldwide. Iron, a central co-factor in various metabolic pathways, plays an essential role in liver function, but its dysregulation can lead to severe health consequences. Accumulation of iron within hepatic cells over time is linked to increased liver injury and is strongly associated with sensitive exposure to a range of conditions, including cirrhosis, fibrosis and ultimately, HCC. This review explores the intricate interplay between iron metabolism and HCC within the context of HBV infection. Hepatic iron overload can arise from liver injury and disruptions in iron homeostasis, causing hepatic necrosis, inflammation, and fibrosis, ultimately culminating in carcinogenesis. Moreover, alterations in serum iron components in HBV-related scenarios have been observed to impact the persistence of HBV infection. Notably, the progression of HBV-associated liver damage exhibits distinct characteristics at various stages of liver disease. In addition to elucidating the complex relationship between iron metabolism and HCC in the context of HBV infection, this review also investigates the prognostic implications of systemic iron levels for HCC. Furthermore, it aims to provide a comprehensive understanding of the intricate interplay between iron metabolism and HCC, extending the discussion to the context of hepatitis C virus (HCV) infection. By shedding light on these multifaceted connections, this review aims to contribute to our understanding of the pathogenesis of HBV-associated HCC and potentially identify novel therapeutic avenues for intervention.