The role of endothelial glycocalyx in sepsis

The role of endothelial glycocalyx in sepsis

The surface of endothelial cells is filled with various membrane-bound molecules that form the glycocalyx. The endothelial glycocalyx is a surface layer mainly consisted of glycosaminoglycans that include heparan sulfate, chondroitin sulfate, and hyaluronic acid and its core proteins. Previous studi...

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Bibliographic Details
Published in:Bali journal of anesthesiology Vol. 3; no. 1; pp. 27 - 32
Main Authors: Budi Hartawan, INyoman, Wiryana, Made
Format: Journal Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019
Subjects:
function
glycocalyx
proteoglycans
shedding
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Summary:The surface of endothelial cells is filled with various membrane-bound molecules that form the glycocalyx. The endothelial glycocalyx is a surface layer mainly consisted of glycosaminoglycans that include heparan sulfate, chondroitin sulfate, and hyaluronic acid and its core proteins. Previous studies suggest that endothelial surface glycocalyx shedding could play a role in endothelial dysfunction and inflammation. This article will review the endothelial glycocalyx and its role in sepsis.
ISSN:2549-2276
2549-2276
DOI:10.15562/bjoa.v3i1.114