A Comprehensive Review of Synthetic Approaches Toward Lamellarin D and its Analogous

• Published in: ChemistrySelect (Weinheim) Vol. 9; no. 37
• Main Authors: Sivaganesan, Pooja, VL, Subiksha, Sahoo, Arupratan, Elanchezhian, Chibisree, Nataraj, Gokulprasanth, Chaudhuri, Saikat
• Format: Journal Article
• Language: English
• Published: 04-10-2024
• Subjects: Coumarin; Cyclization; Debenzylation; Lamellarin D; pyrrole fushed isoquinoline; Suzuki Coupling
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.202403112

Lamellarin D, a naturally occurring molecule, isolated from marine molluscs, it exhibits potent pharmacological activities, such as topoisomerase I inhibition, antiproliferation, antiviral, insecticidal, antimetastatic and anticancer effects, making it a promising candidate for drug development. This review explores the synthesis of Lamellarin D employing various methodologies. These synthetic approaches have enabled researchers to access Lamellarin D and its analogous efficiently, facilitating further investigation into their biological properties. Our study summarizes the major contributions of these efforts to the larger synthetic community, primarily focusing on general synthetic techniques toward the Lamellarin D and its counterpart since its isolation in 1997 to the present.
Synthetic approaches toward the complex natural Marine alkaloid Lamellarin D are reviewed, including successful total syntheses, published synthetic efforts. The review focuses on general synthetic strategies and summarizes the major contributions of these efforts to the larger synthetic community, primarily focusing on general synthetic techniques toward the Lamellarin D and its counterpart since its isolation in 1997 to the present.