Cover Feature: Ultrabright Terbium Nanoparticles for FRET Biosensing and in Situ Imaging of Epidermal Growth Factor Receptors (Chem. Eur. J. 64/2020)

Novel trifunctional ligands enable simultaneous bioconjugation (e.g., to antibodies), attachment to nanoparticle surfaces, and photosensitization of Tb ions, affording ultrabright biofunctionalized Tb nanoparticles. These luminescent nanoparticle bioconjugates were successfully implemented in time‐g...

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Bibliographic Details
Published in:	Chemistry : a European journal Vol. 26; no. 64; p. 14505
Main Authors:	Charpentier, Cyrille, Cifliku, Vjona, Goetz, Joan, Nonat, Aline, Cheignon, Clémence, Cardoso Dos Santos, Marcelina, Francés‐Soriano, Laura, Wong, Ka‐Leung, Charbonnière, Loïc J., Hildebrandt, Niko
Format:	Journal Article
Language:	English
Published:	17-11-2020
Subjects:	bio-labeling FRET lanthanide nanoparticles luminescence microscopy time-resolved detection
Online Access:	Get full text
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Summary:	Novel trifunctional ligands enable simultaneous bioconjugation (e.g., to antibodies), attachment to nanoparticle surfaces, and photosensitization of Tb ions, affording ultrabright biofunctionalized Tb nanoparticles. These luminescent nanoparticle bioconjugates were successfully implemented in time‐gated FRET spectroscopy and luminescence microscopy for homogeneous in‐solution biosensing and live‐cell imaging of EGFR transmembrane receptors. More information can be found in the Full Paper by L. J. Charbonnière, N. Hildebrandt, et al. on page 14602.
Bibliography:	These authors contributed equally to this work.
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.202003301