Using Siglec-engaging Tolerance-inducing Antigenic Liposomes (STALs) to reduce memory B cell responses to the major peanut allergen Ara h 2

Using Siglec-engaging Tolerance-inducing Antigenic Liposomes (STALs) to reduce memory B cell responses to the major peanut allergen Ara h 2

[...]mice were challenged with a high dose of Ah2. Conclusions A single dose of Ah2 STALs suppressed the memory B-cell response to Ah2, demonstrating viability of a novel approach to targeted deletion of allergen-specific memory B-cells that is considered to be an ultimate source for long-term aller...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology Vol. 141; no. 2; p. AB200
Main Authors: Hardy, LaKeya C., Orgel, Kelly, Duan, Shiteng, Maleki, Soheila J., Burks, A. Wesley, Paulson, James C., Macauley, Matthew, Kulis, Michael D.
Format: Journal Article
Language:English
Published: St. Louis Elsevier Inc 01-02-2018
Elsevier Limited
Subjects:
Allergens
Allergies
Ara h 2 antigen
Body temperature
Immunological memory
Immunological tolerance
Liposomes
Lymphocytes B
T cell receptors
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Summary:[...]mice were challenged with a high dose of Ah2. Conclusions A single dose of Ah2 STALs suppressed the memory B-cell response to Ah2, demonstrating viability of a novel approach to targeted deletion of allergen-specific memory B-cells that is considered to be an ultimate source for long-term allergies
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.634